Tag Archives: Genetics

What is Meiosis?

By | September 8, 2021

In the previous posts we looked into eukaryotic cell division (Mitosis) and its regulation at checkpoints. Today we will discuss about another important type of cell division called as Meiosis. Introduction : Meiosis is a special kind of cell division that occur in germ cells of sexually reproducing organisms, where it reduces the chromosome number… Read More »

Enhancers and Genetics

By | July 10, 2021

Enhancers They are short DNA fragments with several prominent features such as: driving the expression of the target gene, orientation relative to a target gene promoter, functionally independent of genomic distance, sensitivity towards DNase treatment (since its neucleosome free region), functional influence over chromatin architecture by allowing binding of transcription co-activators and histone acetylation, and… Read More »

What is Epigenetics?

By | June 29, 2021

Genes and behavior Even though identical twins come from the same genetic material, they turn out to be very different people looking alike. So different that one of the twins could get a genetic disorder at the age of 40 and the other could be the most fit person! Why is that so? Epigenetics: The… Read More »

Abnormal accumulation of proteins in neurodegenerative disorders

By | June 29, 2021

Alzheimer’s disease: A microtubule-binding protein called tau abnormally aggregates in the nerve cells, glia, and extracellular space in Alzheimer’s disease. These accumulated tau molecules are highly phosphorylated and are arranged into long, thin polymers that wind around one another to form helical filaments. The helical filaments form bundles in dendrites, axon, and cell bodies that… Read More »

Epigenetic regulation in the developing cerebral cortex/brain

By | June 29, 2021

The cerebral cortex or brain is a complex organ because millions of circuits involving various neuronal subtypes give rise to complex behavior or specific function. This process of neuronal circuit formation involved a complex network of transcriptional control of specification and plasticity of neurons. FEZF2 is one such transcription factor that is essential for the… Read More »

How to make a recombinant fly line

By | June 14, 2021

Ease of doing genetic experiments makes Drosophila an excellent model system to study development and disease. The reasons for ease in setting up genetic crosses and its subsequent interpretation of results can be attributed to many efficient genetic tools, balancer chromosomes, innumerable genetic markers with clear visible phenotype, mutants for many genes and less number… Read More »

Transgenesis in Drosophila melanogaster

By | April 17, 2021

The wide array of genetic tools available for Drosophila makes it one of popular eukaryotic model system to study numerous biological questions concerning development, genetics,evolution, cell biology, neuroscience and disease. We so far talked about UAS GAL4 system and P element mutagenesis and today we look into another very pivotal genetic tool used to study… Read More »

P-Element mutagenesis in Drosophila

By | April 17, 2021

There has been a long history of innovation and development of tools for gene discovery and genetic analysis in Drosophila melanogaster. This includes methods to induce mutations and to screen for those mutations that disrupt specific processes, methods to map mutations genetically and physically, and methods to clone and characterize genes at the molecular level.Modern… Read More »

Over Expression in Drosophila – The UAS-GAL4 Binary System

By | April 15, 2021

The reason for Drosophila melanogaster being a very successful model system when compared to other equally beautiful model organisms in the field will be its short life cycle, cheap to maintain in lab, availability of BALANCER CHROMOSOME’S , many offspring’s, feature-rich morphology (various genetic markers) and not to forget wide array of genetic tools. The… Read More »