Tag Archives: Brain

Abnormal accumulation of proteins in neurodegenerative disorders

By | June 29, 2021

Alzheimer’s disease: A microtubule-binding protein called tau abnormally aggregates in the nerve cells, glia, and extracellular space in Alzheimer’s disease. These accumulated tau molecules are highly phosphorylated and are arranged into long, thin polymers that wind around one another to form helical filaments. The helical filaments form bundles in dendrites, axon, and cell bodies that… Read More »

Epigenetic regulation in the developing cerebral cortex/brain

By | June 29, 2021

The cerebral cortex or brain is a complex organ because millions of circuits involving various neuronal subtypes give rise to complex behavior or specific function. This process of neuronal circuit formation involved a complex network of transcriptional control of specification and plasticity of neurons. FEZF2 is one such transcription factor that is essential for the… Read More »